1) Indianapolis Colts- Andrew Luck (QB, Stanford)
The Colts have been a lock to pick Stanford QB Andrew Luck for months. While the team will give due diligence to Robert Griffin III and scout him, but Luck is the man here. Indy will begin a new era this season, and what better way to replace Manning than with the best quarterback prospect since, well, Manning. Luck can make all the throws and looked great throughout his college career and at his pro day. It almost seems unfair that a team can get to draft franchise quarterbacks back to back like this.
Other Possibilities: Robert Griffin III

2) Washington Redskins (from St. Louis)- Robert Griffin III (QB, Baylor)
The Redskins sold the farm to move up to the 2nd spot in order to land their quarterback of the future. Griffin has elite athleticism and can make all the throws. The differences in Luck and Griffin are mainly just style of play. Both are talented. Griffin seems to be a great fit for the Redskins and the West Coast offense. He possesses great character and can be a leader in the locker room for years to come. Either way, the Redskins will get a great quarterback.
Other possibilities: Andrew Luck